Historically, most Ossiflex™ has been canine-sourced. Due to a shortage of suitable canine donors that would allow the processing of Ossiflex™ graft, our most recent batch is equine sourced. For more information on the use of equine Ossiflex™ across a variety of species as xenografts, please see the "Cross Species Use" tab above.
Membranes are flexible grafts that have a variety of applications. They are available in different forms: Ossiflex™ (flexible bone membranes) and Fascia (fascia lata grafts). Each has different handling characteristics, but all serve to provide a membrane barrier and guide. All VTS membrane products are biocompatible and biodegradable and ultimately are replaced by the patient’s own tissues, no removal is necessary. They can be sutured into place.
In dentistry they are primarily used as a barrier for Guided Tissue/Bone Regeneration purposes to prevent premature epithelial and fibroblast in-growth into areas of bone healing. They can also be used to bridge bone defects (e.g., cleft palates), close fistulae (e.g. oro-nasal fistulae).
In orthopedics, fascia grafts can be used to bolster partially ruptured tendons or patch dural or rotator cuff defects.
Ossiflex™ Bone Membranes from VTS are thin, flexible sheets made of natural demineralized cortical bone. These are thicker than the other membranes, and being made of cortical bone provide a natural surface compatible with bony integration as well as epithelialization.
Size 1: 1.0 x 1.0 cm
|Indications: GTR on small breeds, small cranio-maxillo facial defects, small canal openings
Size 2: 1.0 x 1.5 cm
|Indications: GTR on medium breeds, medium cranio-maxillo facial defects, medium canal openings
Size 3: 1.5 x 2.0 cm
|Indications: GTR on large breeds, large cranio-maxillo-facial defects, large canal openings
Size 3L: 1.5 x 4.0 cm
|Indications: Long, narrow cranio-maxillo-facial defects
Size 4: 2.0 x 3.0 cm
Indications: Very large cranio-maxillo-facial defects, fracture bridging
Size 5: 3.0 x 3.5 cm
|Indications: Very large cranio-maxillo-facial defects, fracture bridging
✔ Guided Tissue Regeneration (GTR) 1-6
✔ Oronasal Fistulas
✔ Cleft Palates
✔ Cranio Facial Defects
✔ Fracture Bridging
✔ Mandibular Canal Protection
|Guided Tissue Regeneration
|Placing a membrane between bone graft and soft tissue avoids premature soft tissue in-growth. 1-6
|While thin and flexible, Ossiflex™ Bone Membranes are strong enough to keep food particles from traveling through oronasal defects.
|Cleft Palates and Cranio-Facial Defects
|Ossiflex™ Bone Membranes are also ideal for treating cranio-maxillo-facial defects. For example, they can be used to support mucoperiosteal advancement flaps for closure of palatal defects.
|Ossiflex™ Bone Membranes can be wrapped around mandibular fractures to support healing.
|Mandibular Canal Protection
|Ossiflex™ Bone Membranes can be placed over open mandibular canals to keep growing tissue from impinging the nerve.
Implanting processed bone graft across species lines is successful because immunogenic markers are disrupted and removed during processing. Modern tissue bank processing methods substantially remove these immunogenic elements and diminish any rejection responses. These days even in humans, no matching is required for bone grafts, not even blood group matching, and millions of bone and tendon grafts are successfully transplanted in people each year. No living cells and minimal cellular elements remain in the grafts to stimulate an immune response; furthermore, irradiation also reduces immunogenicity. These steps make modern, processed grafts very different from past eras where fresh frozen grafts were used in with more limited success.
Another important feature to consider is that bone growth factors are well-conserved across species, so much so that the growth factors in almost all types of bone effectively stimulate osteoprogenitors from a wide variety of different species. A prime example that most vets have heard of is that human Bone Morphogenic Protein (BMP-2) is very effective in canines for example. In fact, the most routinely used osteoinductivity assay for bone grafts from all species, including humans, relies on the responsiveness of mouse-derived osteoprogenitor cell lines.