{"product_id":"ossiflex™-bone-membranes","title":"Ossiflex™ Bone Membranes","description":"\u003cp\u003e\u003cem\u003eHistorically, most Ossiflex™ has been canine-sourced.  Due to a shortage of suitable canine donors that would allow the processing of Ossiflex™ graft, our most recent batch is equine sourced. For more information on the use of equine Ossiflex™ across a variety of species as xenografts, please see the \"Cross Species Use\" tab above.\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eMembranes are flexible grafts that have a variety of applications. They are available in different forms: Ossiflex™ (flexible bone membranes) and Fascia (fascia lata grafts). Each has different handling characteristics, but all serve to provide a membrane barrier and guide. All VTS membrane products are biocompatible and biodegradable and ultimately are replaced by the patient’s own tissues, no removal is necessary. They can be sutured into place.\u003cbr\u003e\u003cbr\u003e In dentistry they are primarily used as a barrier for Guided Tissue\/Bone Regeneration purposes to prevent premature epithelial and fibroblast in-growth into areas of bone healing. They can also be used to bridge bone defects (e.g., cleft palates), close fistulae (e.g. oro-nasal fistulae).\u003cbr\u003e\u003cbr\u003e In orthopedics, fascia grafts can be used to bolster partially ruptured tendons or patch dural or rotator cuff defects.\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eOssiflex™ Bone Membranes\u003c\/strong\u003e from VTS are thin, flexible sheets made of natural demineralized cortical bone. These are thicker than the other membranes, and being made of cortical bone provide a natural surface compatible with bony integration as well as epithelialization.\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 181.05px;\"\u003e\n\u003cstrong\u003eSize 1: \u003c\/strong\u003e\u003cspan\u003e1.0 x 1.0 cm\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003e(Freeze-Dried)\u003c\/span\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 339.35px;\"\u003eIndications: GTR on small breeds, small cranio-maxillo facial defects, small canal openings\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 181.05px;\"\u003e\n\u003cstrong\u003eSize 2: \u003c\/strong\u003e\u003cspan\u003e1.0 x 1.5 cm\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003e(Freeze-Dried)\u003c\/span\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 339.35px;\"\u003eIndications: GTR on medium breeds, medium cranio-maxillo facial defects, medium canal openings\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 181.05px;\"\u003e\n\u003cstrong\u003eSize 3: \u003c\/strong\u003e\u003cspan\u003e1.5 x 2.0 cm\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003e(Freeze-Dried)\u003c\/span\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 339.35px;\"\u003eIndications: GTR on large breeds, large cranio-maxillo-facial defects, large canal openings\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 181.05px;\"\u003e\n\u003cstrong\u003eSize 3L: \u003c\/strong\u003e\u003cspan\u003e1.5 x 4.0 cm\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003e(Freeze-Dried)\u003c\/span\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 339.35px;\"\u003eIndications: Long, narrow cranio-maxillo-facial defects\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 181.05px;\"\u003e\n\u003cstrong\u003eSize 4: \u003c\/strong\u003e2.0 x 3.0 cm\u003cbr\u003e(Freeze-Dried)\u003c\/td\u003e\n\u003ctd style=\"width: 339.35px;\"\u003e\n\u003cp\u003eIndications: Very large cranio-maxillo-facial defects, fracture bridging\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 181.05px;\"\u003e\n\u003cstrong\u003eSize 5: \u003c\/strong\u003e3.0 x 3.5 cm\u003cbr\u003e\u003cspan\u003e(Freeze-Dried)\u003c\/span\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 339.35px;\"\u003e\u003cspan\u003eIndications: Very large cranio-maxillo-facial defects, fracture bridging\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cbr\u003e\u003cstrong\u003eIndications\u003c\/strong\u003e\u003cbr\u003e ✔ Guided Tissue Regeneration (GTR) 1-6\u003cbr\u003e ✔ Oronasal Fistulas\u003cbr\u003e ✔ Cleft Palates\u003cbr\u003e ✔ Cranio Facial Defects\u003cbr\u003e ✔ Fracture Bridging\u003cbr\u003e ✔ Mandibular Canal Protection\u003cbr\u003e\u003cbr\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 35%;\"\u003e\u003cstrong\u003eGuided Tissue Regeneration\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003ePlacing a membrane between bone graft and soft tissue avoids premature soft tissue in-growth. 1-6\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 35%;\"\u003e\u003cstrong\u003eOronasal Fistulas\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eWhile thin and flexible, Ossiflex™ Bone Membranes are strong enough to keep food particles from traveling through oronasal defects.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 35%;\"\u003e\u003cstrong\u003eCleft Palates and Cranio-Facial Defects\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eOssiflex™ Bone Membranes are also ideal for treating cranio-maxillo-facial defects. For example, they can be used to support mucoperiosteal advancement flaps for closure of palatal defects.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 35%;\"\u003e\u003cstrong\u003eFracture Bridging\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eOssiflex™ Bone Membranes can be wrapped around mandibular fractures to support healing.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 35%;\"\u003e\u003cstrong\u003eMandibular Canal Protection\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eOssiflex™ Bone Membranes can be placed over open mandibular canals to keep growing tissue from impinging the nerve.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cdiv class=\"hidden\"\u003e\n\u003cul id=\"customNavTab\"\u003e\n\u003cli\u003e\u003ca href=\"#collapse-tabA\" data-toggle=\"tab\"\u003eCross Species Use\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv class=\"tab-content\" id=\"customTabContent\"\u003e\n\u003cdiv class=\"tab-pane fade\" id=\"collapse-tabA\"\u003eGrafts from VTS are routinely used across a variety of species as xenografts. Many veterinarians use canine bone in their feline and other patients routinely and effectively. Our Fusion Xpress bone putty is sourced from equine bone and is effectively used in canines and felines every day. Our canine and equine bone grafts have been used successfully in many exotic or wild animals, including seals, birds, porcupine, and other injured animal species. \u003cbr\u003e\u003cbr\u003e Implanting processed bone graft across species lines is successful because immunogenic markers are disrupted and removed during processing. Modern tissue bank processing methods substantially remove these immunogenic elements and diminish any rejection responses. These days even in humans, no matching is required for bone grafts, not even blood group matching, and millions of bone and tendon grafts are successfully transplanted in people each year. No living cells and minimal cellular elements remain in the grafts to stimulate an immune response; furthermore, irradiation also reduces immunogenicity. These steps make modern, processed grafts very different from past eras where fresh frozen grafts were used in with more limited success. \u003cbr\u003e\u003cbr\u003e Another important feature to consider is that bone growth factors are well-conserved across species, so much so that the growth factors in almost all types of bone effectively stimulate osteoprogenitors from a wide variety of different species. A prime example that most vets have heard of is that human Bone Morphogenic Protein (BMP-2) is very effective in canines for example. In fact, the most routinely used osteoinductivity assay for bone grafts from all species, including humans, relies on the responsiveness of mouse-derived osteoprogenitor cell lines.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"iM3","offers":[{"title":"Equine \/ 1","offer_id":39254750363750,"sku":"IM-EBOXFD1","price":121.75,"currency_code":"CAD","in_stock":false},{"title":"Equine \/ 2","offer_id":39254750396518,"sku":"IM-EBOXFD2","price":199.0,"currency_code":"CAD","in_stock":false},{"title":"Equine \/ 3","offer_id":39254750429286,"sku":"IM-EBOXFD3","price":349.5,"currency_code":"CAD","in_stock":false},{"title":"Equine \/ 3L","offer_id":39254750462054,"sku":"IM-EBOXFD3L","price":786.0,"currency_code":"CAD","in_stock":false},{"title":"Equine \/ 4","offer_id":39254750494822,"sku":"IM-EBOXFD4","price":921.0,"currency_code":"CAD","in_stock":false},{"title":"Canine \/ 1","offer_id":39254750167142,"sku":"IM-CBOXFD1","price":121.75,"currency_code":"CAD","in_stock":false},{"title":"Canine \/ 2","offer_id":39254750199910,"sku":"IM-CBOXFD2","price":199.0,"currency_code":"CAD","in_stock":false},{"title":"Canine \/ 3","offer_id":39254750232678,"sku":"IM-CBOXFD3","price":349.5,"currency_code":"CAD","in_stock":false},{"title":"Canine \/ 3L","offer_id":39254750265446,"sku":"IM-CBOXFD3L","price":786.0,"currency_code":"CAD","in_stock":false},{"title":"Canine \/ 4","offer_id":39254750298214,"sku":"IM-CBOXFD4","price":921.0,"currency_code":"CAD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2358\/3885\/products\/Ossiflex_Bone_Membranes_1-3_03b12398-bb2f-489a-87cd-afde4a3f1fcd.jpg?v=1746164994","url":"https:\/\/serona.ca\/products\/ossiflex%e2%84%a2-bone-membranes","provider":"Serona Animal Health Limited","version":"1.0","type":"link"}